Scientist II ADC Medicinal Chemistry

Scientist II ADC Medicinal Chemistry

Location: Location: Tsukuba, Ibaraki, Japan

General Information

Job Advert Title: Scientist II, ADC Medicinal Chemistry

Location: Tsukuba, Ibaraki

Division: Oncology Research

Employment Class: Permanent

Description

About Astellas

Astellas is a global life sciences company committed to turning innovative science into VALUE for patients. We provide transformative therapies in disease areas that include oncology, ophthalmology, urology, immunology and women's health. Through our research and development programs, we are pioneering new healthcare solutions for diseases with high unmet medical need. (HP: Learn more about Astellas)

Are you driven to make a real difference in the lives of patients?

We're seeking passionate individuals who thrive in dynamic environments, embrace new ideas, and aren't afraid to take intelligent risks. People who act with unwavering integrity and are deeply committed to making a tangible impact.

Purpose & Scope

Recent advances in drug discovery targeting cancer have been remarkable, and Astellas is constantly challenging next-generation modalities such as cell therapy, gene therapy, and multifunctional antibodies, as well as new cancer biology. Under such circumstances, we have successfully delivered innovative treatment drugs such as XOSPATA, XTANDI, and PADCEV to cancer patients. Furthermore, we are currently promoting drug discovery research by combining multifunctional modality and the biological understanding of TME in the Primary Focus "Immuno-Oncology" established though our Focus Area approach.

We are urgently recruiting people who will participate in the challenge of driving a paradigm shift in cancer treatment together with our team. We welcome applications from those who can persistently plan and carry out research with innovative ideas and a spirit of challenge, and lead research projects as a member of the global team.

Essential Job Responsibilities

The position is expected to lead drug discovery programs that utilizes genetically modified technology for cancer treatment, and will be in charge of the following tasks.

1. In view of science and trends in the ADC related field, establish next-generation ADCs that can be expected to have innovative therapeutic benefits
2. Design and synthesis of payloads, linkers and ADCs which includes investigation and analysis of patents, literatures and reviews related to our researching therapeutic area as well as carrying out organic reactions, conjugations, purifications and structure analysis to identify a compound suitable for clinical testing
3. Provides appropriate guidance to younger members on complex issues that arise in ADC research. He/she will also mentor and train younger members of the team in the projects for which he/she is responsible, thereby enhancing the scientific expertise of the team.
4. May be responsible for research outsourced to CROs, such as outsourced synthesis, or in research collaboration with external partners.
5. Contribute to the creation of innovative Oncology Research pipeline through the above ADC research activities.

Specific Physical or Environmental Requirements

• This position is based in Tsukuba Research center and will require on-site work.
• (OR) At Astellas we recognize the importance of work/life balance, and we are proud to offer a hybrid working solution allowing time to connect with colleagues at the office with the flexibility to also work from home. We believe this will optimize the most productive work environment for all employees to succeed and deliver. Hybrid work from certain locations may be permitted in accordance with Astellas' Responsible Flexibility Guidelines.

Qualifications

Required

• PhD with 5+ years or MS with 8+ years of relevant experience in medicinal chemistry.
• Strong knowledge of medicinal chemistry
• Experience in serving as a lead chemist in oncology projects
• Experimental skills necessary to carry out ADC research (both small molecule synthesis and ADC conjugation)
• Strong interpersonal and verbal/written communication skills
• Build strong relationships with peers and partners outside
• Business level communication skill in English (Japanese communication skill is not mandatory in case applicants are non-Japanese)

Application Documents

Resumes

Selection details

CV screening → First interview → Final interview

• Please be advised that there might be a change in the process.

Location

Tsukuba, Ibaraki

Start Date

Will be decided according to the candidate's flexibility

Contract Duration

Not limited to specified period

Probation Period

No probation period in principle

Salary

1 Base salary: will be decided by the candidate's experience, skill and capability.

2 When Discretionary Work System is applied: Discretionary work allowance will be paid.(50,000～100,000yen, based on the Grade)

3 When Flextime System is applied: Overtime allowance will be paid for time worked in excess of prescribed working hours.

Salary Raise

Bonus

Allowance

Discretionary work allowance, Housing allowance, Commutation allowance, etc.

Working Hours

8:30～17:30（Mon～Thu）、8:30～15:45（Fri）

Discretionary Work System

Holidays

Weekends(Sat and Sun), holidays, May 1st, summer vacation, New Year holidays

Vacation Leave

Annual paid leave, childcare leave system, nursing care leave system, etc.

Welfare

Employment Insurance, Industrial Accident Compensation Insurance, Welfare Pension Insurance, Health Insurance, Mutual Aid Association System, Company Housing System, Employee Shareholder Association System, Property Accumulation Savings System

"We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by

•Global collaboration: Become part of a connected global business of like-minded life science leaders, all dedicated to improving patients' lives worldwide. 

•Real-world patient impact: Contribute to transformative therapies that reach patients around the world, knowing your work makes a difference every day.

•Relentless Innovation: Join a company at the forefront of scientific breakthroughs, where you'll have the opportunity to shape the future of healthcare. 

•A Culture of Growth: Chart your own course within a supportive environment that values your contributions, champions your development, and empowers you to pursue your passions. 

Our Organizational Values and Behaviors

Values: Innovation, Integrity and Impact sit at the heart of what we do. 

Behaviors: We come together as ‘One Astellas’, working with courage and a sense of urgency. We are outcome focused and consistently take accountability for our personal contribution.